“It wasn’t just faster, it gave us confidence to make critical decisions earlier”: How Rivia Enabled Real-Time Adaptive Dosing

Background

In a Phase 2, open-label study, Jesse and his team faced the challenge of running an adaptive dose modification design while keeping safety front and center. Traditional processes would have meant days of back and forth before making dosing calls. With Rivia, the team had real-time access to integrated data, giving them not only speed but also the confidence to act on emerging signals at the patient level.

How Rivia Helped

Informed Decisions at the Company Level

With earlier clarity on patient response and safety trends, leadership could make strategic calls that shaped both the study and broader development plans.

"Having real-time data allowed us to make key strategic decisions, not only for the clinical trial, but for the company.”

Early Safety Monitoring

The team began with Rivia to track adverse events and safety labs, spotting emerging trends and outliers that could otherwise have been missed.

“It enables us to get key relevant information faster than I have ever encountered.”

Expanding Across the Study

After seeing impact in safety, they expanded use to eligibility screening, efficacy trends, and exploring baseline characteristics predictive of response.

Adaptive Dosing Made Real

With real-time access, investigators and the study team could discuss patient-level dosing decisions dynamically. Adjustments were made promptly, aligned with emerging clinical outcomes.

“We had patient diary data, and because it fed seamlessly into the Rivia platform, we were able to assess patients on a daily basis and measure their disease activity.”

Self-Service Access

Rather than routing requests through operations or biostatistics, multiple team members directly explored and adjusted variables in real time.

“For the first time, I could explore variables myself without waiting on statisticians or programmers. The answers were immediate.”

Integrated Data Environment

Rivia unified data from patient diaries, labs, safety reports, pharmacodynamics, and imaging, delivering a consolidated view that improved both speed and confidence in decision-making.

“Rivia gave us one view that brought diaries, labs, safety reports, and imaging together. There was no longer the need to piecing things together.”

Results

Rivia gave the sponsor team clarity not only at the trial level but at the company level. Faster insights and integrated data supported strategic decisions about development direction, resource allocation, and risk management. The study team operated with greater speed and precision, while leadership gained confidence to make earlier calls that shaped the future of their program.

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